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Soft Tissue Pathology Flashcards
INI1 is a tumor supressor gene located on chromosome 22 (22q11.2). It is expressed in all nucleated post-natal cells. Loss of nuclear expression of INI1 is characteristic of what tumors?
- Epithelioid sarcoma (including proximal type)
- Rhabdoid tumor (rhabdoid tumor of the kidney, extrarenal malignant rhabdoid tumor, and atypical teratoid/rhabdoid tumor of the CNS)